A report, “Immunotherapy of hepatoma with a monoclonal antibody against murine endoglin,” is newly published data in World Journal of Gastroenterology. In this recent report, researchers in Haikou, People’s Republic of China conducted a study “To explore the capability of a monoclonal antibody (mAb) against murine endoglin to inhibit tumor angiogenesis and suppression of hepatoma growth in murine models. A monoclonal antibody against murine endoglin was purified by affinity chromatography and passively transfused through tail veins in two murine hepatoma models.”
“Tumor volume and survival time were observed at three-day intervals for 48 d. Microvessels in tumor tissues were detected by immunohistochemistry against CD31, and angiogenesis in vivo was determined by alginate encapsulated assay. In addition, tumor cell apoptosis was detected by TUNEL assay. Passive immunotherapy with anti-endoglin mAb could effectively suppress tumor growth, and prolonged the survival time of hepatoma-bearing mice. Angiogenesis was apparently inhibited within the tumor tissues, and the vascularization of alginate beads was also reduced in the mice passively transfused with anti-endoglin mAb,” wrote G.H. Tan and colleagues, Medical College.

The researchers concluded: “In addition, increased apoptotic cells were observed within the tumor tissues from the mice passively transfused with anti-endoglin mAb. Passive immunotherapy with anti-endoglin mAb effectively inhibits tumor growth via inhibiting tumor angiogenesis and increasing tumor cell apoptosis, which may be highly correlated with the blockage of endoglin-related signal pathway induced by anti-endoglin mAb.”

Tan and colleagues published their study in World Journal of Gastroenterology (Immunotherapy of hepatoma with a monoclonal antibody against murine endoglin. World Journal of Gastroenterology, 2007;13(17):2479-83).

For additional information, contact G.H. Tan, Hainan Provincial Key Laboratory of Tropical Medicine, Hainan Medical College, Haikou 571101, Hainan Province, China.

Publisher contact information for the World Journal of Gastroenterology is: W J G Press, PO Box 2345, Beijing 100023, People’s Republic of China.