- MONDAY, Aug. 25 (HealthDay News) — Low or high levels of LDL
cholesterol are associated with an increased risk of cancer in patients
with type 2 diabetes, according to a Chinese study that noted the
increasing evidence of an association between type 2 diabetes and cancer
risk.

The study included 6,107 diabetes patients. None of the patients were
taking cholesterol-lowering statins.

The researchers found that LDL levels below 2.80 mmol/L were associated
with an increased risk of cancers of the digestive organs and peritoneum,
genital and urinary organs, and lymphatic and blood tissues. LDL levels
above 3.80 mmol/L were associated with increased risk of oral, digestive,
bone, skin, connective tissue and breast cancers.

The findings suggest “the use of these levels as risk markers may help
clinicians to assess their patients more fully and thus to prevent
premature deaths in patients who have high risk,” wrote the team from the
Hong Kong Institute of Diabetes and Obesity, the Li Ka Shing Institute of
Health Sciences and The Chinese University of Hong Kong.

The study was published in the Canadian Medical Association
Journal.

The researchers recommended a re-analysis of data from clinical trials
to confirm or refute their findings.

Confounding factors such as lifestyle, socioeconomic status and
indication for use of statins need to be considered when examining the
association between LDL levels and cancer risk, Drs. Frank Hu and Eric
Ding of the Harvard School of Public Health, wrote in an accompanying
commentary.

“Low serum cholesterol is commonly observed in individuals with ill
health (e.g., cancer patients) and those with unhealthy lifestyle
characteristics such as smoking and heavy drinking,” they noted.

More information

The U.S. Centers for Disease Control and Prevention has more about diabetes.